ATAD3A mediates activation of RAS-independent mitochondrial ERK1/2 signaling, favoring head and neck cancer development.

Liwei LangReid LovelessJuan DouTiffany LamAlex ChenFang WangLi SunJakeline JuarezZhaohui Steve QinNabil F SabaChloe ShayYong Teng

Published in: Journal of experimental & clinical cancer research : CR (2022)

These findings highlight the novel function of ATAD3A in regulating mitochondrial ERK1/2 activation that favors HNSCC development. Combined targeting of ATAD3A and RAS signaling may potentiate anticancer activity for HNSCC therapeutics.

Keyphrases

signaling pathway
oxidative stress
cell proliferation
pi k akt
wild type
small molecule