The neuro-protective role of telomerase via TERT/TERF-2 in the acute phase of spinal cord injury.
Dong Gune ChangJang-Woon KimHong Jin KimYoung Hoon KimSang Il KimKee-Yong HaPublished in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2023)
Increased TERT and TERF-2 activity were noted 24 h post-injury in the acute phase of SCI with TERF-2 maintaining telomeric-repeat length. Our results suggest that increased activity of telomere maintenance may be related to neuro-protective mechanisms against subsequent apoptosis resulting from DNA damage after acute SCI.