A catalytic triplex DNAzyme for porphyrin metalation.

Xiong ZhengMujing YangTong YangYun ChangShuzhen PengQiuda XuDandan WangXiaoshun ZhouYong Shao

Published in: Chemical communications (Cambridge, England) (2021)

Trihydroxyphenyl porphyrin (POH3) was designed to specifically bind with a triplex DNA resulting in a turn-on fluorescence response. This ensemble can be developed into a catalytic triplex DNAzyme towards porphyrin metalation. The catalytic activity is initiated by the enhanced basicity of POH3 upon binding with the triplex DNA.

Keyphrases

single molecule
living cells
photodynamic therapy
energy transfer
circulating tumor
metal organic framework
cell free
fluorescent probe
electron transfer
crystal structure
binding protein
convolutional neural network
machine learning
quantum dots