YAP1 status defines two intrinsic subtypes of LCNEC with distinct molecular features and therapeutic vulnerabilities.
C Allison StewartLixia DiaoYuanxin XiRunsheng WangKavya RamkumarAlejandra Griselda SerranoAzusa TanimotoB Leticia RodriguezBenjamin B MorrisLi ShenBingnan ZhangYan YangSamera H HamadRobert J CardnellAlberto DuarteMoushumi SahuVeronica Y NovegilBernard E WeissmanMichael FrumovitzNeda KalhorLuisa Maren Solis SotoPedro RochaNatalie I VokesDon L GibbonsJing WangJohn Victor HeymachBonnie GlissonLauren Averett ByersCarl M GayPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
YAP1 defines distinct subsets of LCNEC with unique biology. These findings highlight the potential for YAP1 to guide personalized treatment strategies for LCNEC.
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