Molecular mechanism of albumin in suppressing invasion and metastasis of hepatocellular carcinoma.

Xiao FuYixuan YangDa-Zhi Zhang

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

ALB acts as a tumour suppressor and plays a key role in HCC progression, particularly in invasion and metastasis. Suppression of ALB promoted migration and invasion of HCC cells by increasing uPAR, matrix metalloproteinase (MMP2), and MMP9.

Keyphrases

cell migration
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
cell proliferation