STAT3 promotes tumour progression in glioma by inducing FOXP1 transcription.

Xinlin SunJihui WangMin HuangTaoliang ChenJiansheng ChenFabing ZhangHuijun ZengZhimin XuYiquan Ke

Published in: Journal of cellular and molecular medicine (2018)

In summary, STAT3 gene was a transcriptional regulator of FOXP1. Depleted STAT3 restrained cell proliferation and invasion, promoted cell apoptosis in glioma cells. This molecular mechanism between STAT3 and FOXP1 can serve as a therapeutic target for glioma treatment.

Keyphrases

regulatory t cells
cell proliferation
transcription factor
gene expression
dendritic cells
genome wide
copy number
mesenchymal stem cells
immune response
oxidative stress
heat shock
combination therapy
heat shock protein