Translational control in neurovascular brain development.
Kleanthi ChalkiadakiElpida StatoullaMaria MarkouSofia BellouEleni BagliTheodore FotsisCarol MurphyChristos G GkogkasPublished in: Royal Society open science (2021)
The human brain carries out complex tasks and higher functions and is crucial for organismal survival, as it senses both intrinsic and extrinsic environments. Proper brain development relies on the orchestrated development of different precursor cells, which will give rise to the plethora of mature brain cell-types. Within this process, neuronal cells develop closely to and in coordination with vascular cells (endothelial cells (ECs), pericytes) in a bilateral communication process that relies on neuronal activity, attractive or repulsive guidance cues for both cell types and on tight-regulation of gene expression. Translational control is a master regulator of the gene-expression pathway and in particular for neuronal and ECs, it can be localized in developmentally relevant (axon growth cone, endothelial tip cell) and mature compartments (synapses, axons). Herein, we will review mechanisms of translational control relevant to brain development in neurons and ECs in health and disease.
Keyphrases
- gene expression
- induced apoptosis
- cerebral ischemia
- endothelial cells
- cell cycle arrest
- white matter
- single cell
- resting state
- cell therapy
- dna methylation
- healthcare
- blood brain barrier
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- transcription factor
- mesenchymal stem cells
- cell proliferation
- brain injury
- pi k akt
- optical coherence tomography
- human health