Safety, tolerability, pharmacokinetics, and pharmacodynamics of oral JNJ-64794964, a TLR-7 agonist, in healthy adults.

Edward GaneMina PastagiaUllrich SchwertschlagAn De CreusChristian SchwabeJoris VandenbosscheLeen SlaetsBart FeveryIlham SmyejLiviawati S WuRui LiSamia SiddiquiAbbie OeyClark MustoPieter Van Remoortere

Published in: Antiviral therapy (2021)

In healthy adults, JNJ-4964 was generally well-tolerated, exhibited dose-proportional pharmacokinetics and induced cytokines/ISGs, with possible anti-HBV activity.

Keyphrases

hepatitis b virus
high glucose
diabetic rats
toll like receptor
inflammatory response
open label
immune response
liver failure
drug induced
oxidative stress
nuclear factor
stress induced