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The growth-survival trade-off is hard-wired in the Lactococcus lactis gene regulation network.

Onur ErcanHeidy M W den BestenEddy J SmidMichiel Kleerebezem
Published in: Environmental microbiology reports (2022)
Most microbes reside in oligotrophic environments for extended periods of time, requiring survival strategies that maintain proliferative capacity. We demonstrate that the non-spore-forming Lactococcus lactis KF147 progressively activates the expression of stress-associated functions in response to the declining growth rate elicited by prolonged retentostat cultivation, which coincides with up to 10 4 -fold increased stress tolerance. Our findings provide a quantified view of the transcription and stress-tolerance adaptations underlying the growth-survival trade-off in L. lactis, and exemplify the hard-wiring of this trade-off in the lactococcal gene regulation network.
Keyphrases
  • stress induced