MBL2 gene polymorphisms and its relation to infection in Brazilian systemic lupus erythematosus patients: A 10-years follow-up study.
Carla Forgiarini SaldanhaGabriela Kniphoff da SilvaNadine GlesseJoão Carlos Tavares BrenolRicardo Machado XavierJosé Artur Bogo ChiesOdirlei Andre André MonticieloPublished in: Lupus (2022)
The presence of the HY promoter haplotype associated to fewer in hospital care for infection treatment probably due to higher MBL plasma levels. Also, HY haplotype and older age at SLE diagnosis is related to less admissions for infection. This factor should be taken into consideration, since infection is a very import cause of mortality in SLE patients being also related to aggressive immunosuppressive treatment.
Keyphrases
- systemic lupus erythematosus
- end stage renal disease
- healthcare
- ejection fraction
- newly diagnosed
- chronic kidney disease
- disease activity
- physical activity
- gene expression
- rheumatoid arthritis
- palliative care
- cardiovascular disease
- cardiovascular events
- patient reported outcomes
- risk factors
- pain management
- health insurance
- smoking cessation
- replacement therapy