Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes.

Kamel MohammediYawa AboulekaCharlyne CarpentierLouis PotierSeverine DuboisNinon FoussardVincent RigalleauJean-François GautierPierre GourdyGuillaume CharpentierRonan RousselAndré ScheenBernard BauduceauSamy HadjadjFrançois Alhenc-GelasMichel MarreGilberto Velho

Published in: Diabetes care (2021)

This report is the first of an independent association between ACE D allele and excess LLA risk, mainly minor amputations, in patients with type 1 diabetes.

Keyphrases

lower limb
type diabetes
angiotensin converting enzyme
angiotensin ii
glycemic control
cardiovascular disease
insulin resistance
adipose tissue
skeletal muscle