Accurate detection of reactive oxygen species by tuning an elastic motif (GPGGA) 4 in nanopores.

We have developed a reactive oxygen species (ROS) sensor based on nanopores modified with GGGCEG(GPGGA) 4 CEG. The formation of an intramolecular disulfide bond oxidized by ROS leads to conformation changes in GGGCEG(GPGGA) 4 CEG, which then induces an obvious change in the size of the nanopores and a corresponding ionic current change. This work allows the accurate and dynamic monitoring of ROS through the combination of (GPGGA) 4 and nanopores.