Cytoprotective Effect of Vitamin D on Doxorubicin-Induced Cardiac Toxicity in Triple Negative Breast Cancer.

Kevin J LeeGriffin WrightHannah BryantLeigh Ann WigginsValeria L Dal ZottoMichele SchulerChristopher MalozziMichael V CohenNatalie R Gassman

Published in: International journal of molecular sciences (2021)

Vitamin D supplementation decreased Dox-induced cardiotoxicity by decreasing the reactive oxygen species and mitochondrial damage, and did not decrease the anticancer efficacy of Dox against TNBC.

Keyphrases

oxidative stress
diabetic rats
reactive oxygen species
high glucose
drug induced
drug delivery
left ventricular
cancer therapy