Sodium Tanshinone IIA Sulfonate Attenuates Tumor Oxidative Stress and Promotes Apoptosis in an Intermittent Hypoxia Mouse Model.
Xiao-Bin ZhangXiao-Yang ChenPeng SunXiao-Man SuHui-Qing ZengYi-Ming ZengMiao WangXiongbiao LuoPublished in: Technology in cancer research & treatment (2021)
Intermittent hypoxia treatment resulted in high oxidative stress and low apoptosis in Lewis lung carcinoma-implanted mice, which could be attenuated by sodium tanshinone IIA sulfonate administration possibly through a mechanism mediated by the nuclear factor erythroid 2-related factor 2/nuclear factor kappa B signaling pathway.
Keyphrases
- heat shock
- nuclear factor
- oxidative stress
- toll like receptor
- induced apoptosis
- mouse model
- signaling pathway
- diabetic rats
- dna damage
- ischemia reperfusion injury
- high intensity
- endothelial cells
- endoplasmic reticulum stress
- pi k akt
- cell cycle arrest
- epithelial mesenchymal transition
- high fat diet induced
- inflammatory response
- type diabetes
- immune response
- metabolic syndrome
- skeletal muscle