Diastereoselective Synthesis of Cycloheptannelated Indoles via Lewis-Acid-Catalyzed (4 + 3)-Cyclization of Donor-Acceptor Cyclopropanes.

Bao Qiong LiZong-Wang QiuAi-Jun MaJin-Bao PengNa FengJi-Yuan DuHan-Peng PanXiang-Zhi ZhangXue-Tao Xu

Published in: Organic letters (2020)

An efficient and straightforward Lewis-acid-mediated stereoselective (4 + 3)-cyclization of indole-substituted alkylidene malonates and donor-acceptor cyclopropanes has been developed involving the Friedel-Crafts/Michael addition cyclization cascade. This reaction provides a mild and effective method for the construction of synthetically and structurally interesting functionalized cycloheptannelated indoles.

Keyphrases

solar cells
energy transfer
quantum dots
molecular docking
ionic liquid
molecular dynamics simulations
simultaneous determination
solid phase extraction