Pilot study of humanized glypican-3-targeted zirconium-89 immuno-positron emission tomography for hepatocellular carcinoma.
Lindsay Kathleen DickersonAdrienne L LehnertDonald K HamlinKevin P LabadieKristin E GoodsellYongjun LiuYawen LiD Scott WilburRobert MiyaokaJames O ParkPublished in: Research square (2024)
Humanized αGPC3 successfully targeted GPC3 in vitro and in vivo. 89Zr-αGPC3H immunoPET had comparable tumor detection to 89Zr-αGPC3M, with highly specific tumor uptake, making it a promising strategy to improve HCC detection.