Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells.

Lin LiXiaoyan HuJewel NkwochaKanika SharmaMaciej KmieciakHashim MannLiang Zhou Steven Grant

Published in: Cellular oncology (Dordrecht) (2023)

Collectively, these findings argue for a non-canonical role for the ATR kinase in STAT3 activation in MM cells, and suggest that STAT3 inactivation contributes to the lethal actions of ATR inhibitors in MM.

Keyphrases

induced apoptosis
cell cycle arrest
cell proliferation
endothelial cells
multiple myeloma
oxidative stress
cell death