Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis.

Hao PanYuqing LinJianping DouZhen FuYanqing YaoShanyu YeSaixia ZhangNeng WangAijun LiuXican LiFengxue ZhangDongfeng Chen

Published in: Cell proliferation (2020)

Our results indicate that wedelolactone promotes the Ser/Thr phosphorylation of NLRP3 to inhibit inflammasome activation and pyroptosis partly through potentiating PKA signalling, thus identifying its potential use for treating MSU-induced peritonitis and gouty arthritis.

Keyphrases

nlrp inflammasome
protein kinase
rheumatoid arthritis
high glucose
oxidative stress
endothelial cells