One Clever Macrophage Checkpoint.
Alberto MantovaniRaffaella BonecchiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Macrophages are a key component of the tumor microenvironment (TME). Blocking Clever-1, a molecule expressed in M2-like macrophages, unleashed macrophage and T-cell-mediated antitumor immunity. Myeloid checkpoints including Clever-1 hold promise as alternative or complementary immunotherapy strategies.See related article by Viitala et al., p. 3289.