Transcriptome analysis reveals overlap in fusion genes in a phase I clinical cohort of TNBC and HGSOC patients treated with buparlisib and olaparib.

Julia EismannYujing J HengJohannes M WaldschmidtIoannis S VlachosKathryn P GrayUrsula A MatulonisPanagiotis A KonstantinopoulosCharles J MurphySheida NabaviGerburg M Wulf

Published in: Journal of cancer research and clinical oncology (2019)

In summary, this study provides the first characterization of fusion genes in a cohort of TNBC and HGSOC patients. An improved mechanistic understanding of fusion genes will support the future identification of innovative therapeutic approaches for these challenging diseases.

Keyphrases

bioinformatics analysis
genome wide
end stage renal disease
genome wide identification
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
genome wide analysis
peritoneal dialysis
dna methylation
patient reported outcomes