A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles.
Arnab BanerjeeVitor AlvesTiago RondãoJosé SerenoÂngela NevesMiguel M LinoAndreia RibeiroAntero José AbrunhosaLino S FerreiraPublished in: Nanoscale (2019)
Here we report a two-step surface modification methodology to radiolabel small extracellular vesicles (SEVs) with 64CuCl2 for PET/MRI imaging. The modification did not change or damage the morphology, surface receptor proteins and internal RNA content. Radiolabeled SEVs could be detected in organs with low accumulation such as the brain (0.4-0.5% ID g-1) and their brain location determined by MRI.
Keyphrases
- positron emission tomography
- computed tomography
- magnetic resonance imaging
- contrast enhanced
- pet ct
- diffusion weighted imaging
- pet imaging
- resting state
- white matter
- high resolution
- magnetic resonance
- oxidative stress
- cerebral ischemia
- multiple sclerosis
- brain injury
- high throughput
- fluorescence imaging
- subarachnoid hemorrhage