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Novel Potent and Selective DPP-4 Inhibitors: Design, Synthesis and Molecular Docking Study of Dihydropyrimidine Phthalimide Hybrids.

Ahmed A E MouradAhmed E KhodirSameh SaberMai A E Mourad
Published in: Pharmaceuticals (Basel, Switzerland) (2021)
Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.
Keyphrases
  • molecular docking
  • molecular dynamics simulations
  • anti inflammatory
  • type diabetes
  • adipose tissue
  • metabolic syndrome
  • skeletal muscle
  • insulin resistance
  • weight loss