Association of IL-1β, NLRP3, and COX-2 Gene Polymorphisms with Autoimmune Thyroid Disease Risk and Clinical Features in the Iranian Population.

Zahra Heidari Saeedeh Salimi Mohsen Rokni Mahnaz Rezaei Neshat Khalafi Mahdieh Jafari Shahroudi Azizallah Dehghan Mohsen Saravani

Published in: BioMed research international (2021)

The results manifest the significant impact of IL-1β rs1143634 and COX-2 (rs2745557) SNPs and HT development and IL-1β rs1143634 SNP on GD occurrence risk. Furthermore, a significant relationship was observed between some clinical features of HT and GD groups and studied SNPs.

Keyphrases

genome wide
risk assessment
multiple sclerosis
dna methylation
gene expression