Matrix Metalloproteinase-7 in Urinary Extracellular Vesicles Identifies Rapid Disease Progression in Autosomal Dominant Polycystic Kidney Disease.
Martijn H van HeugtenCharles J BlijdorpSita ArjuneHester van WilligenburgKarel BezstarostiJeroen A A DemmersUsha Musterd-BhaggoeEsther MeijerRon T GansevoortRobert ZietseSikander HayatRafael KramannRoman-Ulrich MüllerMahdi SalihEwout J Hoornnull nullPublished in: Journal of the American Society of Nephrology : JASN (2023)
Among patients with ADPKD, rapid disease progressors have higher uEV-associated MMP-7. Our findings also suggest that MMP-7 is a biologically plausible biomarker for more rapid disease progression.