Staphylococcus aureus From an Acute Fracture-related Infection Displays Important Bacteriological and Histopathologic Differences From a Chronic Equivalent in a Murine Bone Infection Model.
Susanne BaertlLena GensDirk NehrbassEric T SumrallStephan ZeiterGopala Krishna MannalaMarkus RuppNike WalterR Geoff RichardsT Fintan MoriartyVolker AltPublished in: Clinical orthopaedics and related research (2023)
For translational use, virulence profiles of S. aureus may be useful in guiding treatment decisions in the future. Once specific virulence targets are identified, one approach to fracture-related infections with high-virulence strains might be the development of antivirulence agents, particularly to treat or prevent septic dissemination. For fracture-related infections with low virulence, prolonged antimicrobial therapy or exchange of an indwelling implant might be beneficial owing to slower growth and persistence capacity.
Keyphrases
- staphylococcus aureus
- escherichia coli
- biofilm formation
- pseudomonas aeruginosa
- antimicrobial resistance
- liver failure
- drug induced
- intensive care unit
- acute kidney injury
- hip fracture
- candida albicans
- body composition
- hepatitis b virus
- respiratory failure
- extracorporeal membrane oxygenation
- bone loss
- aortic dissection