Optimization of Metformin in the GRADE Cohort: Effect on Glycemia and Body Weight.
William I SivitzLawrence S PhillipsDeborah J WexlerStephen P FortmannAnne W CampMargaret TiktinMagalys PerezJacqueline CraigPriscilla A HollanderAndrea CherringtonVanita R ArodaMeng Hee TanJonathan KrakoffNeda RasouliNicole M ButeraNaji Younesnull nullPublished in: Diabetes care (2020)
Optimizing metformin to 2,000 mg/day or a maximally tolerated lower dose combined with emphasis on medication adherence and lifestyle can improve glycemia in type 2 diabetes and HbA1c values ≥6.8% (51 mmol/mol). These findings may help guide efforts to optimize metformin therapy among persons with type 2 diabetes and suboptimal glycemic control.