Stabilizing tumor resident mast cells restores T cell infiltration and sensitizes sarcomas to PD-L1 inhibition.

Myrofora Panagi Fotios Mpekris Chrysovalantis Voutouri Andreas G Hadjigeorgiou Chloe Symeonidou Eleni Porfyriou Christina Michael Andreas Stylianou John D Martin Horacio Cabral Anastasia Constantinidou Triantafyllos Stylianopoulos

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our study suggests the targeting of MCs with clinically administered drugs, such as antihistamines, as a promising approach to overcome resistance to immunotherapy in sarcomas.

Keyphrases

high grade
patient safety
quality improvement
induced apoptosis
drug delivery