Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders.

Liye ZhouZexian ZengAnn Marie EgloffFan ZhangFei GuoKatie M CampbellPeter DuJingxin FuPaul ZolkindXiaojing MaZhe ZhangYi ZhangXiaoqing WangShengqing GuRachel RileyYasutaka NakahoriJoshua KeeganRobert I HaddadJonathan D SchoenfeldObi GriffithRobert T MangusoJames A LedererX Shirley LiuRavindra Uppaluri

Published in: Journal for immunotherapy of cancer (2022)

These data highlight critical aspects of CD8 +TIL heterogeneity and differentiation and suggest facilitation of CD8 +TIL differentiation as a strategy to improve HNSCC ICB response.

Keyphrases

dna damage
single cell
nk cells
diabetic rats
big data
drug induced
deep learning