Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
Alejandro M HortalClara L OesteClaudia CifuentesMiguel AlcocebaIsabel Fernández-PisoneroLaura ClavaínRut TerceroPilar MendozaVerónica DomínguezMarta García-FloresBelén PintadoDavid AbiaCarmen García-MacíasAlmudena Navarro-BailónXosé R BusteloMarcos GonzálezBalbino AlarcónPublished in: Molecular cancer (2022)
The results indicate that overexpression of wild type RRAS2 is behind the development of CLL.