Activity of cefepime/taniborbactam and comparators against whole genome sequenced ertapenem-non-susceptible Enterobacterales clinical isolates: CANWARD 2007-19.

Alyssa R GoldenMelanie R BaxterJames A KarlowskyLaura MatasejeMichael R MulveyAndrew WalktyDenice C BayFrank SchweizerPhilippe R S Lagace-WiensHeather J AdamGeorge G Zhanel

Published in: JAC-antimicrobial resistance (2022)

Cefepime/taniborbactam was highly active against ENSE with various antimicrobial resistance phenotypes/genotypes. ENSE isolates with cefepime/taniborbactam MIC values ≥ 4 mg/L possessed combinations of β-lactam resistance mechanisms, including β-lactamase genes, as well as alterations in OmpC and/or OmpF and/or PBP3.

Keyphrases

antimicrobial resistance
gram negative
escherichia coli
multidrug resistant
genome wide
klebsiella pneumoniae
genetic diversity
bioinformatics analysis