Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns.

Wei GuanLei ZhouYan LiErna YangYangyang LiuNa LvLin FuYi DingNan WangNan FangQian LiuBinan WangFuwei LiJuan ZhangMaoquan WangLili WangYu JingYonghui LiLiping Dou

Published in: Experimental hematology & oncology (2021)

Our study offers deep insights into the molecular pathogenesis and biology of AML with FLT3-ITD and FLT3-TKD by providing the profiles of concurrent molecular alterations and the clinical impact of FLT3-ITD and FLT3-TKD on AML patients.

Keyphrases

acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
ejection fraction
newly diagnosed
genome wide
tyrosine kinase
gene expression
squamous cell carcinoma
dna methylation
prognostic factors
patient reported outcomes
transcription factor
rectal cancer
locally advanced