Hierarchical lncRNA regulatory network in early-onset severe preeclampsia.

Haihua LiuZhijian WangYanjun LiQian ChenSijia JiangYue GaoJing WangYali ChiJie LiuXiaoli WuQiong ChenChaoqun XiaoMei ZhongChunlin ChenXinping Yang

Published in: BMC biology (2024)

Our results suggest that the differential expression of lncRNAs may perturb the lncRNA-TF-DEG hierarchical regulatory network, leading to the dysregulation of many genes involved in EOSPE. Our study provides a new strategy and a valuable resource for studying the mechanism underlying gene dysregulation in EOSPE patients.

Keyphrases

early onset
late onset
end stage renal disease
newly diagnosed
ejection fraction
transcription factor
chronic kidney disease
prognostic factors
peritoneal dialysis
copy number
gene expression
pregnant women