Two Furanharzianones with 4/7/5/6/5 Ring System from Microbial Transformation of Harzianone.
Min ZhangJimei LiuRidao ChenJinlian ZhaoKebo XieDawei ChenKeping FengJun-Gui DaiPublished in: Organic letters (2017)
Furanharzianones A and B (2 and 3), two new harziane-type diterpenoids with a tetrahydrofuran and unusual 4/7/5/6/5 ring system, were obtained from the microbial transformation of harzianone (1) by a bacterial strain Bacillus sp. IMM-006. The structures, including the stereochemistry, of the two new compounds were elucidated by extensive spectroscopic analysis. The absolute configuration of 2 was unambiguously determined by single-crystal X-ray diffraction. In addition, a plausible bioconversion pathway was proposed.