Variants of ACAN are associated with severity of lumbar disc herniation in patients with chronic low back pain.

Romain Shanil PereraPoruwalage Harsha DissanayakeUpul SenarathLalith Sirimevan WijayaratneAranjan Lional KarunanayakeVajira Harshadeva Weerabaddana Dissanayake

Published in: PloS one (2017)

SNVs of ACAN and their haplotypes are associated with the severity of lumbar disc herniation. Functional genetic studies are necessary to identify the role of these significant SNVs in the pathogenesis of disc herniation.

Keyphrases

minimally invasive
copy number
genome wide
case control
gene expression