Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus.
Yusuke TakeshimaYukiko IwasakiMasahiro NakanoYuta NarushimaMineto OtaYasuo NagafuchiShuji SumitomoTomohisa OkamuraKeith ElkonKazuyoshi IshigakiAkari SuzukiYuta KochiKazuhiko YamamotoKeishi FujioPublished in: Annals of the rheumatic diseases (2022)
This work elucidated the potential prognostic marker for SLE. Since OXPHOS consists of the electron transport chain, a functional unit in mitochondria, these findings suggest the importance of mitochondrial dysfunction as a key immunological pathway involved in SLE.