A connectivity mapping approach predicted acetylsalicylic acid (aspirin) to induce osteo/odontogenic differentiation of dental pulp cells.
R RankinFionnuala T LundyBettina C SchockS-D ZhangB Al-NatourI AboutC IrwinG J LindenIkhlas A El-KarimPublished in: International endodontic journal (2020)
Connectivity mapping, a web-based informatics method, was successfully used to identify aspirin as a candidate drug that could modulate the differentiation of DPCs. Aspirin was shown to induce odontogenic differentiation in DPCs in vitro and this, together with its anti-inflammatory effects, makes it a potential candidate for vital pulp therapies.
Keyphrases
- low dose
- cardiovascular events
- antiplatelet therapy
- high resolution
- resting state
- induced apoptosis
- white matter
- functional connectivity
- high density
- risk assessment
- coronary artery disease
- multiple sclerosis
- machine learning
- electronic health record
- mass spectrometry
- percutaneous coronary intervention
- endoplasmic reticulum stress
- cell death
- human health
- adverse drug
- drug induced