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Atypical evolution of meningiomatosis after discontinuation of cyproterone acetate: clinical cases and histomolecular characterization.

Thibault PasseriLorenzo GiammatteiTuan Le VanRosaria AbbrittiAlexandre PerrierJennifer WongChristine BourneixMarc PolivkaHoma Adle-BiassetteAnne-Laure BernatJulien Masliah-PlanchonEmmanuel MandonnetSébastien Froelich
Published in: Acta neurochirurgica (2021)
To our knowledge, this is the first report describing an atypical tumor evolution of CPA-associated meningiomas after CPA discontinuation. The underlying biological mechanisms explaining this observation and especially the close relationship between mutational landscapes and embryologic origins of the meninges in CPA-related meningiomas as well as their clonal origin require further research.
Keyphrases
  • healthcare
  • drug induced