Plasma steroid concentrations reflect acute disease severity and normalise during recovery in people hospitalised with COVID-19.
Kerri DevineClark D RussellGiovanny R BlancoBrian R WalkerNatalie Z M HomerScott G DenhamJoanna P SimpsonOlivia C LeavyOmer ElneimaHamish J C McAuleyAarti ShikotraAmisha SingapuriMarco SerenoRuth M SaundersVictoria C HarrisLinzy Houchen-WolloffNeil J GreeningNazir I LoneMathew ThorpeWilliam GreenhalfJames D ChalmersLing-Pei HoAlex HorsleyMichael MarksBetty RamanShona C MooreJake DunningMalcolm G SempleRuth AndrewLouise V WainRachael A EvansChristopher E BrightlingJohn Kenneth BaillieRebecca M Reynoldsnull nullPublished in: Clinical endocrinology (2024)
Circulating glucocorticoids in patients hospitalised with COVID-19 reflect acute illness, with a marked rise in cortisol and fall in male testosterone. These findings are not observed 5 months from discharge. The lack of association between hormone concentrations and common post-COVID symptoms suggests steroid insufficiency does not play a causal role in this condition.
Keyphrases
- coronavirus disease
- sars cov
- liver failure
- end stage renal disease
- respiratory failure
- chronic kidney disease
- ejection fraction
- newly diagnosed
- drug induced
- respiratory syndrome coronavirus
- peritoneal dialysis
- prognostic factors
- intensive care unit
- patient reported outcomes
- depressive symptoms
- acute respiratory distress syndrome
- physical activity
- mechanical ventilation