The Statistical Fragility of Tranexamic Acid Use in the Orthopaedic Surgery Literature: A Systematic Review of Randomized Controlled Trials.

Ashley N BrownAvanish YendluriKyle W LawrenceJohn K CorderoCalin S MouchaBrett L HaydenRobert L Parisien

Published in: The Journal of the American Academy of Orthopaedic Surgeons (2024)

Statistical outcomes reported in RCTs on the use of TXA in orthopaedic surgery are fragile. Reversal of a few outcomes is sufficient to alter statistical significance. We recommend reporting FI, rFI, and FQ metrics to aid in interpreting the outcomes reported in comparative trials.

Keyphrases

minimally invasive
coronary artery bypass
systematic review
emergency department
type diabetes
metabolic syndrome
percutaneous coronary intervention
acute coronary syndrome
insulin resistance