Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model.

Cho-Ming ChaoRhea van den BruckSamantha LorkJanica MerkleLaura KrampenPatrick P WeilMalik AydinSaverio BellusciAndreas C JenkeJan Postberg

Published in: Clinical epigenetics (2018)

Early hyperoxia induced permanent changes in histones signatures at the NOS3 and STAT3 gene locus might partly explain the altered vascular response patterns in children with BPD.

Keyphrases

genome wide
mouse model
nitric oxide synthase
dna methylation
cell proliferation
high glucose
pulmonary hypertension
young adults
diabetic rats
copy number
nitric oxide
oxidative stress
gene expression
endothelial cells
genome wide identification
transcription factor
genome wide analysis