Specific Hepatic Sphingolipids Relate to Insulin Resistance, Oxidative Stress, and Inflammation in Nonalcoholic Steatohepatitis.

Maria ApostolopoulouRuth GordilloChrysi KoliakiSofia GanchevaTomas JelenikElisabetta De FilippoChristian HerderDaniel MarkgrafFrank JankowiakIrene EspositoMatthias SchlensakJennifer H Stern Michael Roden

Published in: Diabetes care (2018)

Sphingolipid species are not only increased in insulin-resistant humans with NASH but also correlate with hepatic oxidative stress and inflammation, suggesting that these lipids may play a role during progression of simple steatosis to NASH in humans.

Keyphrases

oxidative stress
insulin resistance
type diabetes
diabetic rats
ischemia reperfusion injury
high fat diet
dna damage
induced apoptosis
adipose tissue
metabolic syndrome
high fat diet induced
glycemic control
polycystic ovary syndrome
skeletal muscle
signaling pathway
weight loss