Sushi domain-containing protein 4 binds to epithelial growth factor receptor and initiates autophagy in an EGFR phosphorylation independent manner.
Konstantinos S PapadakosAlexander EkströmPiotr SlipekEleni SkourtiSteven ReidKristian PietrasAnna M BlomPublished in: Journal of experimental & clinical cancer research : CR (2022)
In this study we provide novel insight into the molecular mechanism of action whereby SUSD4 acts as an EGFR inhibitor without affecting the phosphorylation of the receptor and may potentially influence the recycling of EGFR to the plasma membrane.