Neurotoxicity and management of primary and secondary CNS lymphoma after adoptive immunotherapy with CD19-directed CAR T-cells.
Philipp KarschniaIsabel C Arrillaga-RomanyApril EichlerDeborah A ForstElizabeth GerstnerJustin T JordanIna LyScott R PlotkinNancy WangMaria Martinez-LageSebastian F WinterJoerg-Christian TonnKai RejeskiLouisa von BaumgartenDaniel P CahillBrian V NahedGanesh M ShankarJeremy S AbramsonJeffrey A BarnesAreej R El-JawahriEphraim P HochbergP Connor Connor JohnsonJacob D SoumeraiRonald W TakvorianYi-Bin ChenMatthew J FrigaultJorg DietrichPublished in: Neuro-oncology (2023)
CAR T-cells exhibit promising anti-tumor effects and a favourable safety profile in CNS lymphoma. Further evaluation of the role of bridging regimens and corticosteroids is warranted.