Targeting Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension (BPD-PH): Potential Role of the FGF Signaling Pathway in the Development of the Pulmonary Vascular System.
Cho-Ming ChaoLei ChongXuran ChuAmit ShresthaJudith BehnkeHarald EhrhardtJinsan ZhangChengshui ChenSaverio BellusciPublished in: Cells (2020)
More than 50 years after the first description of Bronchopulmonary dysplasia (BPD) by Northway, this chronic lung disease affecting many preterm infants is still poorly understood. Additonally, approximately 40% of preterm infants suffering from severe BPD also suffer from Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH), leading to a significant increase in total morbidity and mortality. Until today, there is no curative therapy for both BPD and BPD-PH available. It has become increasingly evident that growth factors are playing a central role in normal and pathologic development of the pulmonary vasculature. Thus, this review aims to summarize the recent evidence in our understanding of BPD-PH from a basic scientific point of view, focusing on the potential role of Fibroblast Growth Factor (FGF)/FGF10 signaling pathway contributing to disease development, progression and resolution.
Keyphrases
- pulmonary hypertension
- preterm infants
- signaling pathway
- pulmonary artery
- pulmonary arterial hypertension
- low birth weight
- pi k akt
- epithelial mesenchymal transition
- neoadjuvant chemotherapy
- squamous cell carcinoma
- radiation therapy
- induced apoptosis
- oxidative stress
- drug induced
- risk assessment
- early onset
- climate change
- cell proliferation