Parsing digital or analogue TCR performance through piconewton forces.
Aoi AkitsuEiji KobayashiYinnian FengHannah M StephensKristine N BrazinDaniel J MasiEvan H KirpatrickRobert J MallisJonathan S Duke-CohanMatthew A BookerVincenzo CinellaWilliam W FengElizabeth L HollidayJonathan J LeeKatarzyna J ZienkiewiczMichael Y TolstorukovWonmuk HwangMatthew J LangEllis L ReinherzPublished in: bioRxiv : the preprint server for biology (2023)
Quality of ligand recognition in a T-cell repertoire is revealed through application of physical load on clonal T-cell receptor (TCR)-pMHC bonds.