Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice.
Yun-Meng BaiFan YangPiao LuoLu-Lin XieJun-Hui ChenYu-Dong GuanHong-Chao ZhouTeng-Fei XuHui-Wen HaoBing ChenJia-Hui ZhaoCai-Ling LiangLing-Yun DaiQing-Shan GengJi-Gang WangPublished in: Military Medical Research (2023)
TCS modulates the cellular activities and fates of several specific cell types (including hepatocytes, HSCs, endothelial cells, B cells, Kupffer cells and liver capsular macrophages) in the liver, and regulates the ligand-receptor interactions between these cells, thereby promoting the proliferation and activation of HSCs, leading to liver fibrosis. Overall, we provide the first comprehensive single-cell atlas of mouse livers in response to TCS and delineate the key cellular and molecular processes involved in TCS-induced hepatotoxicity and fibrosis.
Keyphrases
- single cell
- liver fibrosis
- rna seq
- high glucose
- induced apoptosis
- endothelial cells
- drug induced
- cell cycle arrest
- high throughput
- liver injury
- diabetic rats
- signaling pathway
- single molecule
- cell death
- type diabetes
- mesenchymal stem cells
- cell proliferation
- adipose tissue
- bone marrow
- insulin resistance
- high fat diet induced