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Mitochondrial GRIM19 Loss Induces Liver Fibrosis through NLRP3/IL33 Activation via Reactive Oxygen Species/NF-кB Signaling.

Xiaohui XuJinmei FengXin WangXin ZengYing LuoXinyu HeMeihua YangTiewei LvZijuan FengLiming BaoLi ZhaoDaochao HuangYi Huang
Published in: Journal of clinical and translational hepatology (2024)
The mitochondrial GRIM19 loss facilitates liver fibrosis through NLRP3/IL33 activation via ROS/NF-кB signaling, providing potential therapeutic approaches for earlier HF prevention.
Keyphrases
  • liver fibrosis
  • reactive oxygen species
  • oxidative stress
  • signaling pathway
  • lps induced
  • pi k akt
  • dna damage
  • nuclear factor
  • cell death
  • inflammatory response
  • toll like receptor