Oropharyngeal Microbiota Clusters in Children with Asthma/Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways and Exacerbations Risk.
Mahmoud I Abdel-AzizJonathan ThorsenSimone HashimotoSusanne J H VijverbergAnne H NeerincxPaul BrinkmanWim van AalderenJakob StokholmMorten Arendt RasmussenMichael Roggenbuck-WedemeyerNadja H VissingMartin Steen MortensenAsker Daniel BrejnrodLouise J FlemingClare S MurrayStephen J FowlerUrs FreyAndrew BushFlorian SingerGunilla HedlinBjörn NordlundDominick E ShawKian Fan ChungIssssswan M AdcockRatko DjukanovicCharles AuffrayAruna T BansalAna R SousaScott S WagersBo Lund ChawesKlaus BønnelykkeSøren Johannes SørensenAletta D KraneveldPeter J SterkGraham C RobertsHans BisgaardAnke H Maitland-van der ZeePublished in: American journal of respiratory and critical care medicine (2023)
The analysis of the oropharyngeal microbiota of children with asthma/wheezing identified four clusters with distinct clinical characteristics (phenotypes) that associate with exacerbations' risk and transcriptomic pathways involved in airway remodeling. This suggests that further exploration of the oropharyngeal microbiota may lead to novel pathophysiological insights and potentially new treatment approaches.