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Activity of ETX0462 toward Some Burkholderia spp.

Elise T ZeiserScott A BeckaJohn J LiPumaKrisztina M Papp-Wallace
Published in: Antimicrobial agents and chemotherapy (2022)
Burkholderia cepacia complex (Bcc) and Burkholderia gladioli are opportunistic human pathogens that are inherently multidrug resistant, limiting treatment options for infections. Here, a novel diazabicyclooctane, ETX0462, was evaluated for activity against Bcc and B . gladioli . Ninety-eight percent of the isolates examined in this study were susceptible. ETX0462 was found to demonstrate in vitro activity superior to that of currently available treatment options (e.g., trimethoprim-sulfamethoxazole and ceftazidime).
Keyphrases
  • multidrug resistant
  • gram negative
  • endothelial cells
  • acinetobacter baumannii
  • pseudomonas aeruginosa
  • induced pluripotent stem cells
  • microbial community
  • antibiotic resistance genes