CD147 mediates epidermal malignant transformation through the RSK2/AP-1 pathway.

Xu ZhangYeye GuoTa XiaoJie LiAiyuan GuoLi LeiChong JinQi LongJuan SuMingzhu YinHong LiuChao ChenZhe ZhouSusi ZhuJuan TaoShuo HuXiang Chen Cong Peng

Published in: Journal of experimental & clinical cancer research : CR (2022)

Our findings demonstrate that CD147 exerts a key function in epidermal malignant transformation in vivo by activating keratinocytes and recruiting MDSCs via the RSK2/AP-1 pathway.

Keyphrases

wound healing
transcription factor
signaling pathway
nk cells